%0 Journal Article
%T Gadd45蛋白家族在肿瘤发生发展中的作用
%A 倪娟
%A 曹宇
%A 曹能
%A 杨国防
%A 汪旭
%A 薛京伦
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1517
%X 摘要 Gadd45蛋白是一种响应环境的应激蛋白，在DNA修复、细胞周期调控及衰老、基因毒性应激反应等多种细胞功能中起着重要的调节作用，该类蛋白包括α，β和γ三种亚型。大量研究结果显示，它们在肿瘤细胞中参与了多种信号通路的调控，与肿瘤的发生及发展关系密切，其表达改变与肿瘤预后息息相关。本文就近年来Gadd45蛋白家族与肿瘤发生发展的研究进展进行简要介绍与阐述
%K Gadd45蛋白
%K 细胞周期
%K 凋亡
%K 自噬
%K 侵袭转移
%K 细胞耐药
%K Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer
%K Effect of ANLN Gene Silencing on Invasion
%K Migration
%K Proliferation and Apoptosis of Gastric Cancer Cells
%K Antitumor and Apoptosis Induction Effects of Gold Nanorods-mediated Near-infrared Photothermal Therapy on Gastric Cancer SGC-7901 Cells in vitro
%K G6PD对大肠癌细胞生长侵袭的影响及其与HKⅡ的相关性
%K Effects of MicroRNA-4465 on Apoptosis and Invasion of Colon Cancer Cells
%K Mechanism of D-bifunctional Protein Promoting Formation of Hepatocellular Carcinoma in Rat via STAT3
%K Regulatory Effect of Astragaloside A on Proliferation and Apoptosis of Human Colon Cancer SW480 Cell Line
%K Effects of Pachymaran on Proliferation
%K Migration and Pro-apoptosis of Human Cervical Carcinoma HeLa Cells and Its Mechanism
%K Anti-tumor Effects of Chlorogenic Acid on Human Glioblastoma Cell Lines U251 and Related Pro-apoptotic Mechanism
%K Apatinib Suppresses Proliferation and Induced Apoptosis of Human Breast Cancer Cell Line MDA-MB-231 Through Glycolytic Inhibition
%K Effects of Long Non-coding RNA-MALAT1 on Proliferation and Apoptosis of Prostate Cancer Cells
%K Expression and Biological Functions of Sestrin2 in Nasopharyngeal Carcinoma
%K RNA PolymeraseⅠInhibitor Regulates Proliferation
%K Invasion and Apoptosis of Nasopharyngeal Carcinoma Cell Line CNE-1 by NF-κb
%K Knockdown of EN2 Induces Apoptosis and Enhances PTEN Protein Expression in Hepatocellular Carcinoma Cells
%K Effect of TAK-242 on Proliferation and Apoptosis of Human Multiple Myeloma Cells
%U http://www.zlfzyj.com/CN/abstract/abstract9362.shtml