%0 Journal Article
%T Integrinβ1和CARMA-3蛋白在膀胱癌组织中的表达与经尿道膀胱肿瘤电切术后复发的相关性
%A 付凤林
%A 张胜利
%A 李群秀
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1182
%X 摘要 目的 探讨膀胱癌组织中Integrinβ1和CARMA-3蛋白的表达及其与患者经尿道膀胱肿瘤电切术后复发的相关性。方法 选取160例经尿道膀胱肿瘤电切术治疗的膀胱癌患者，保留患者病理标本，并对患者随访5年，最终108例纳入研究。根据患者复发情况分为短期复发组和长期首次复发组。免疫组织化学法检测膀胱癌肿瘤组织中Integrinβ1和CARMA-3表达，并分析其表达与经尿道膀胱肿瘤电切术后复发的相关性。结果 短期复发组Integrinβ1和CARMA-3蛋白的表达显著高于长期首次复发组（P<0.05）；Integrinβ1和CARMA-3蛋白的表达与T分期以及分级存在正相关（均P<0.05）；CARMA-3和Integrinβ1蛋白在膀胱癌组织中的表达呈正相关（r=0.774, P<0.05）。结论 CARMA-3和Integrinβ1蛋白是尿道膀胱肿瘤电切术后膀胱癌复发的风险因素
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%U http://www.zlfzyj.com/CN/abstract/abstract9355.shtml