%0 Journal Article
%T 靶向HER2阳性肿瘤的PET/CT分子显像临床研究进展
%A 周妮娜
%A 朱华
%A 杨志
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1016
%X 摘要 人类表皮生长因子受体2（HER2） 在多种肿瘤组织中均有不同程度表达，曲妥珠单抗，可明显提高HER2阳性乳腺癌、胃癌的总生存时间。目前对HER2过表达的检测方法主要是免疫组织化学染色和荧光原位杂交法 ，但这种有创性的检查不能作为肿瘤疗效评价的常规检查而多次进行。靶向HER2的PET/CT分子显像，有望实时、无创监测全身病灶的HER2表达情况。目前靶向HER2的PET/CT分子显像主要包括核素标记抗体显像、核素标记亲和体显像、核素标记抗体片段及纳米抗体显像。靶向HER2的PET/CT显像可用于监测全身病灶的HER2表达情况，监测HER2表达的异质性，可用于原发乳腺癌HER2阴性患者阳性转移灶的筛选，同时也可用于靶向治疗的疗效预测。长半衰期核素铜、锆（64Cu、89Zr）标记完整抗体可直接评估HER2结合Trastuzumab的情况，但其血液药代动力学较慢，血液清除率较慢，需较长时间点的显像，辐射剂量较高。短半衰期核素（68Ga）标记亲和体显像、抗体片段及纳米抗体显像，由于其分子量小，生物分布快，注射药物后可短时间内显像（1~4 h），增加了患者的便利性，可重复显像，亲合体由于与抗体结合位点不同，可用于靶向治疗显像，另外其辐射剂量较低，可能更适于临床应用
%K HER2
%K PET/CT
%K 分子显像
%K 靶向
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%U http://www.zlfzyj.com/CN/abstract/abstract9384.shtml