%0 Journal Article
%T 低剂量氨酚羟考酮片与可待因治疗中度骨转移癌痛的随机对照研究
%A 万复甦
%A 冯刚
%A 胡胜
%A 董爽
%A 蔡茜
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1924
%X 摘要 目的 观察低剂量氨酚羟考酮片在中度骨转移癌痛治疗中的疗效及安全性以及是否优于弱阿片 药物可待因。方法 78例患者按2:1随机接受氨酚羟考酮片或可待因治疗。氨酚羟考酮片起始剂量为1片， 口服，每12小时1次。根据疼痛爆发情况可每8小时1次，氨酚羟考酮片每日总量不超过3片。如出现或疑 似消化道出血、肝肾功能异常者停用氨酚羟考酮片。可待因30 mg每12小时1次。根据疼痛爆发情况可每8 小时1次。主要观察患者近期（72 h）和远期（2周）的疼痛控制情况及不良反应。疼痛程度用数字化评估 量表法（NRS）评估。结果 72 h内单用氨酚羟考酮片NRS降至3分以下：中度疼痛组46/52（88.46%）， 明显高于可待因组16/26（61.54%）（P=0.006）。远期疗效氨酚羟考酮片有效率为63.46%（33/52），高于 可待因组61.54%（16/26），但差异无统计学意义（P=0.868）。不良反应包括恶心、呕吐、嗜睡、便秘等 发生率均较低，两组差异均无统计学意义。结论 强阿片类药物羟考酮可以用于中度疼痛的治疗，低剂 量氨酚羟考酮片比弱阿片药物可待因更有效，即使长期应用，安全性也可以接受
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%U http://www.zlfzyj.com/CN/abstract/abstract9436.shtml