%0 Journal Article
%T 膀胱癌组织中色素上皮衍生因子与雄激素受体的表达及其相关性
%A 卜强
%A 吴爱斌
%A 夏东东
%A 曾明辉
%A 秦锁炳
%A 蒋华
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.19.0132
%X 摘要 目的 探讨膀胱癌组织中色素上皮衍生因子（PEDF）与雄激素受体（AR）的表达及其相关性。方法 采用免疫组织化学染色检测30例膀胱癌组织中PEDF和AR表达，采用Pearson相关性分析PEDF表达与AR之间的关系。Real-time PCR和Western blot检测在不同浓度的雄激素处理下，膀胱癌TCCSUP细胞株中PEDF和AR的表达水平以及慢病毒介导的AR干扰后，细胞株中PEDF的表达水平。结果 相关性分析表明PEDF表达与AR表达呈负相关（P=0.003）。雄激素处理后上调AR表达，抑制PEDF表达。同时，干扰AR的表达可以上调PEDF表达。结论 膀胱癌组织中PEDF的表达可能受到AR表达所抑制
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%U http://www.zlfzyj.com/CN/abstract/abstract9495.shtml