%0 Journal Article
%T 选择性增加PTV单次剂量对食管癌患者预后的影响
%A 李曙光
%A 许金蕊
%A 曹彦坤
%A 沈文斌
%A 祝淑钗
%A 郭娜
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.2007
%X 摘要 目的 探讨选择性增加PTV单次剂量对食管癌患者预后的影响。方法 收集接受治疗的食管癌患者302例，进行预后影响因素分析，并比较不同PTV单次剂量的两组患者的构成比，依据Cox多因素分析结果，应用PSM法进行1:1匹配，分析匹配后两组患者的预后影响因素。结果 全组患者中位OS为30.0月（HR: 3.319, 95%CI: 23.495~36.505），中位DFS为21.3月（HR: 1.838, 95%CI: 7.698~24.902）。多因素分析结果显示，化疗、cTNM分期和PTV单次剂量为OS（均P<0.05）和DFS（均P<0.05）的独立预后影响因素。依据多因素分析结果进行PSM分析，经1:1配比后每组患者90例。PSM后多因素分析结果显示，cTNM分期和PTV单次剂量为患者OS独立预后影响因素；化疗、cTNM分期和PTV单次剂量为患者DFS独立预后影响因素；两组患者≥2级急性不良反应发生率差异无统计学意义（均P>0.05）。SIB-IMRT组中PTV单次剂量为2 Gy和>2 Gy的患者亚组分析结果显示，后者的OS和DFS均显著性优于前者（均P<0.05 ）。结论 选择性增加PTV单次剂量可改善接受根治性放（化）疗食管癌患者的生存情况，而不增加其不良反应
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%U http://www.zlfzyj.com/CN/abstract/abstract9401.shtml