%0 Journal Article
%T 外周血细胞计数及其比值对初诊伴非骨相关髓外病变的多发性骨髓瘤患者预后的评估价值
%A 于泳
%A 井瑶瑶
%A 张翼鷟
%A 杨洪亮
%A 王亚非
%A 王晓芳
%A 赵智刚
%A 赵海丰
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1075
%X 摘要 目的 探讨外周血淋巴细胞计数（ALC）、单核细胞计数（AMC）、淋巴细胞与单核细胞比值（LMR）、血小板与淋巴细胞比值（PLR）与初诊时伴非骨相关髓外病变（sEMD）的多发性骨髓瘤（MM）患者临床病理特征的相关性以及对疗效和生存的影响。方法 收集81例初诊时伴sEMD的MM患者临床病理资料，分别分析外周血ALC、AMC、LMR、PLR与血红蛋白、肌酐水平、乳酸脱氢酶水平、β2微球蛋白水平、治疗疗效、预后生存情况等指标关系。以ALC、AMC、PLR、LMR中位数为界值进行分组。Kaplan-Meier法分析ALC、AMC、PLR、LMR与生存及预后之间的关系；预后多因素分析采用Cox风险回归模型。结果 81例患者ALC、AMC、PLR、LMR中位数分别为1.38×109/L、0.48×109/L、134.9、3.11，多因素分析结果显示：LMR≤3.11（P=0.021）、PLR≥134.9（P=0.019）、LDH≥247U/L（P=0.041）、Hb≤110 g/L（P=0.004）是初诊伴sEMD的MM患者预后不良的影响因素。结论 对于初诊伴sEMD的MM患者，LMR≤3.11、PLR≥134.9、LDH≥247 U/L、Hb≤110 g/L可能是其影响预后不良的独立因素
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%U http://www.zlfzyj.com/CN/abstract/abstract9400.shtml