%0 Journal Article
%T 分化差的胃神经内分泌肿瘤预后分析
%A 张剑
%A 张家丽
%A 张新伟
%A 臧凤琳
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1770
%X 摘要 目的 探讨分化差的胃神经内分泌肿瘤的临床病理特点和辅助治疗对预后的影响。方法 回顾性分析经根治性手术治疗的胃神经内分泌肿瘤124例，根据肿瘤分类标准对肿瘤进行分类、分级和分期，并进行随访，采用Kaplan-Meier法绘制生存曲线，Log rank检验进行单因素分析，Cox比例风险回归模型进行多因素分析。结果 胃神经内分泌瘤、胃神经内分泌癌和混合性腺神经内分泌癌的5年生存率分别为100%、52.4%和38.8%，多因素分析示淋巴结转移与否（P=0.030）和有无辅助治疗（P=0.017），尤其是顺铂联合依托泊苷方案（HR=0.051, P=0.015）是影响胃神经内分泌癌患者的独立预后因素；而淋巴结转移、远处转移、TNM分期和有无辅助治疗均不是混合性腺神经内分泌癌患者的独立预后因素。结论 胃神经内分泌癌患者的预后与淋巴结转移和有无辅助治疗有关，其辅助治疗可以考虑顺铂联合依托泊苷方案
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%U http://www.zlfzyj.com/CN/abstract/abstract9398.shtml