%0 Journal Article
%T 骨肉瘤中miR-17-92基因簇作用的研究进展
%A 卢斌
%A 姜晓玲
%A 王勃霏
%A 蔡惠丽
%A 陈海丹
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.18.1988
%X 摘要 骨肉瘤是一种原发于骨的常见恶性肿瘤，好发于儿童和青少年，长期以来5年生存率不到70%。目前，骨肉瘤的治疗已到达一个平台期，进一步的预后改善可能依赖于新的生物学疗法。miRNA在肿瘤中的作用日益被重视，其中miR-17-92基因簇作为致癌基因，在骨肉瘤中的作用也被广泛研究。本文综述miR-17-92基因簇在骨肉瘤中的功能和机制，以期为骨肉瘤带来新的治疗方案
%K A Case Report and Literature Review
%K Construction of Gene-coregulation-network for Osteosarcoma MicroRNA
%K Effect of miRNA-199a-5p on Cell Proliferation and Autophagy in Osteosarcoma
%K miR-494 Inhibits Proliferation and Invasion of Osteosarcoma Cells MG-63 Through Downregulating Sox9 Expression
%K Effect of Costimulatory Molecule B7-H3 on Invasion and Metastasis of Osteosarcoma Cells and Related Mechanism
%K Advances of Oncogene Cancer-up-regulated Gene 2(CUG2)
%K Mechanism of TG2 Regulating Hypoxia-induced Apoptosis in Osteosarcoma Cell Line MG-63 by Mitochondrial Pathway
%K Effects of microRNA-101 on Invasion and Autophagy of Human Osteosarcoma Cells
%K Clinical Curative Effects of Pemetrexed Combined with Cisplatin in Treatment for Osteosarcoma Patients with Lung Metastasis
%K X-ray
%K CT and MRI Detections of Chondrosarcoma of Ribs
%K Effects of Lobaplatin on Proliferation and Apoptosis of Osteosarcoma MG-63 Cells and Its Mechanism
%U http://www.zlfzyj.com/CN/abstract/abstract9437.shtml