%0 Journal Article
%T 腹腔热灌注联合全身静脉化疗在卵巢癌治疗中的不良反应评价
%A 冯绣程
%A 杨静
%A 汪洋
%A 蔡红兵
%J 肿瘤防治研究
%D 2019
%R 10.3971/j.issn.1000-8578.2019.19.0324
%X 摘要 目的 评价肿瘤细胞减灭术后行腹腔热灌注联合全身静脉化疗在卵巢癌治疗中的不良反应及其对患者生存期的影响。方法 选取163例卵巢癌患者作为研究对象，所有患者均行肿瘤细胞减灭术并按照治疗方法分为观察组（47例）与对照组（116例），观察组为术后行腹腔热灌注联合全身静脉化疗，对照组为术后单纯全身静脉化疗。观察两组患者的不良反应发生情况，并对所有患者进行术后随访。 结果 观察组低蛋白血症发生率高于对照组，而白细胞减少、血小板下降、腹胀及腹痛发生率低于对照组（P<0.05），其余不良反应差异无统计学意义。当患者热灌注次数＞2次时D2聚体升高、低钙血症、血糖升高和恶心呕吐的发生率升高（P<0.05）。两组患者总生存率无显著差异，观察组无贫血或轻度贫血患者生存情况优于重度贫血患者（P<0.05），其余不良反应的发生对患者整体生存率没有显著影响。结论 卵巢肿瘤细胞减灭术后行腹腔热灌注化疗联合静脉化疗并不会增加不良反应、尤其是严重不良反应的发生，但存在低蛋白血症发生率高的特点
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%U http://www.zlfzyj.com/CN/abstract/abstract9534.shtml