%0 Journal Article
%T DCE-MRI Extended tofts模型和Reference Region模型在肺部结节/肿块良恶性诊断中的应用价值<br>Comparative study of Extended tofts model and Reference Region model in DCE-MRI of discriminating benign and malignant pulmonary nodules/masses
%A 杜永浩
%A 梁 挺
%A 杨 健
%A 张 硕
%A 郭银霞
%A 牛 刚
%J 西安交通大学学报(医学版)
%D 2019
%R 10.7652/jdyxb201903014
%X 摘要：目的 对比分析定量动态增强磁共振(DCE-MRI)药代动力学Extended tofts模型与Reference Region模型应用于肺结节/肿块良恶性鉴别诊断中的价值。方法 回顾性分析65例肺部结节/肿块(良性22例，恶性43例)病例资料，所有患者均在CT引导下行肺穿刺活检或手术前行DCE-MRI检查。分别应用Extended tofts和Reference Region模型测量良恶性肺结节/肿块的定量参数：容积转移常数Ktrans(min-1)、组织间隙-血浆速率常数Kep(min-1)、细胞外间隙容积分数Ve(mL)。采用独立样本t检验比较良恶性病变各定量参数之间的差异。以病理结果为金标准绘制ROC曲线评估定量DCE-MRI鉴别肺结节/肿块良恶性的诊断效能。结果 Extended tofts模型中Ktrans、Kep对肺部结节/肿块良恶性有鉴别意义(P<0.05)。Reference Region模型参数Ktrans、Kep在良恶性病变间差异无统计学意义。 结论 在时间分辨率较高的前提下，Extended tofts模型比Reference Region模型更适合应用于肺结节/肿块良恶性鉴别诊断,其定量参数Ktrans较Kep的诊断效能高。<br>ABSTRACT: Objective To investigate and compare the diagnostic values of Extended tofts model and Reference Region model in dynamic contrast enhancement magnetic resonance imaging (DCE-MRI) analysis of benign and malignant pulmonary nodules/masses. Methods For this study, we recruited retrospectively 65 patients with pulmonary nodules/masses (22 benign and 43 malignant) confirmed by pathological results who underwent DCE-MRI by 3.0T MR. The quantitative MR pharmacokinetic parameters including Ktrans, Kep, and Ve were calculated by Extended tofts and Reference Region models. Results The parameters of Extended tofts model Ktrans and Kep were significant in differentiating benign and malignant nodules/masses (P<0.05), while the parameters of Reference Region models Ktrans and Kep did not differ significantly in the differentiation of benign and malignant ones. Conclusion On the premises of high temporal resolution, the Extended tofts model is more appropriate for the diagnosis of benign and malignant pulmonary nodules/masses than the Reference Region model, and its quantitative parameter Ktrans has a higher diagnostic efficiency than Kep
%K 动态对比增强磁共振成像
%K 肺结节/肿块
%K 药代动力学模型
%K 对比研究<br>dynamic contrast enhancement magnetic resonance imaging (DCE-MRI)
%K pulmonary nodule/mass
%K pharmacokinetic model
%K comparative study
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201903014