%0 Journal Article
%T 冠脉个性化给药与常规给药对CCTA图像质量影响的对比研究
Comparative study of using individualized contrast-medium injection protocol to improve contrast uniformity in coronary CT angiography
%A 屈婷婷
%A 焦喜军
%A 李剑颖
%A 白晶晶
%A 宋哲凡
%A 郭建新
%J 西安交通大学学报(医学版)
%D 2019
%R 10.7652/jdyxb201901021
%X 摘要:目的 探讨CT冠脉血管成像(CCTA)中,个性化给药方案对提高血管强化均一性的作用。方法 前瞻性收集CCTA检查患者60例,随机分为实验组和对照组,每组30例。两组患者采用不同的给药方案,实验组采用基于体质量计算碘量的方法:22mg/(kg?s);对照组根据身体质量指数(BMI)确定碘流率,分别为1.2、4、1.6g/s。〖JP〗两组患者均用碘海醇(350mg/mL),注射时间为10s。比较两组患者主动脉根部和三大主干冠脉血管强化程度的变化率有无差异。主观评估图像质量,比较其差异。 结果 两组患者目标血管强化程度的变化率有统计学差异(P=0.001),实验组(12.9%、11.8%、11%、11.1%)明显低于对照组(23.3%、18.7%、16.7%、20.5%)。主观评分无统计学意义(P=0.095)。结论 CCTA检查中,采用个性化对比剂注射方案能获得冠状动脉均一的强化效果,整体提高图像质量。
ABSTRACT: Objective To investigate the effect of individualized contrast administration in improving the enhancement homogeneity in vessels and image quality in coronary CT angiography (CCTA). Methods Sixty CCTA patients were randomly divided into two groups with different contrast injection protocols: treatment group (n=30) was treated with weight-dependent injection protocol at 22mg/(g?s) of idion, injection velocity=body mass×22/contrast agent concentration. Control group (n=30) was treated with a different injection protocol. The iodine flow rate in this group was determined by patient body mass index (BMI), iodine flow rate=1.2g/s, 1.4g/s and 1.6g/s. Injection flow rate= iodine flow rate/contrast agent concentration. Theiohexol (350mg/mL) was used in both groups, and the injection time was fixed at 10s and contrast agent dose=injection velocity×injection time. The other scanning parameters were the same. The enhancement change rate in AS and the three major arteries was calculated for the patient population. The subjective image quality scores were also compared. Results The change rates of vascular enhancement at interested blood vessels in treatment group (12.9%, 11.8%, 11.0% and 11.1%, respectively) were significantly lower than those in in control group (23.3%, 18.7%, 16.7% and 20.5%, respectively) (P=0.001). There was no significant difference between the two groups in subjective image quality score (P=0.095). Conclusion Individualized contrast injection protocol in CCTA can provide us with a more uniform enhancement in coronary arteries, and improve the overall image quality
%K 冠状动脉CT血管成像
%K 个性化给药方案
%K 图像质量
coronary CT angiography
%K individualized contrast-medium injection protocol
%K image quality
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201901021