%0 Journal Article
%T 骨保护素是高血压患者冠脉钙化的独立危险因素并与血管紧张素Ⅱ相关<br>Osteoprotegerin is an independent risk factor for coronary calcification in patients with hypertension and is associated with angiotensin Ⅱ
%A 刁佳宇
%A 赵宏谋
%A 杨 光
%A 韩稳琦
%A 酉鹏华
%A 杨 萌
%A 王 毅
%J 西安交通大学学报(医学版)
%D 2019
%R 10.7652/jdyxb201906013
%X 摘要：目的 评估高血压患者血浆骨保护素(osteoprotegerin, OPG)水平与冠脉钙化之间的关系，以及OPG与血管紧张素Ⅱ(angiotensin Ⅱ, AngⅡ)之间的相关性。方法 研究入选了348例高血压患者，64排冠脉CT检查明确患者冠脉钙化情况，根据钙化评分将高血压患者分为冠脉钙化组与非冠脉钙化组，比较两组患者的临床与实验室指标，计算患者冠脉钙化危险因素的比值比(odds ratio, OR)，以及患者血浆OPG与AngⅡ水平的相关系数。结果 高血压伴冠脉钙化组患者OPG与AngⅡ水平均高于非冠脉钙化患者(P均<0.001)。多因素Logistics回归分析显示，OPG水平(OR 3.728；95% CI 1.314～7.714)与AngⅡ水平(OR 2.385；95% CI 1.281～4.836)均是冠脉钙化独立危险因素(P<0.001)，并且OPG、AngⅡ水平与冠脉钙化的严重程度相关。在高血压伴冠脉钙化患者中，OPG水平与AngⅡ水平呈正相关(P<0.001，r=0.509)；而在非冠脉钙化患者中，OPG水平与AngⅡ水平无关(P>0.05)。结论 OPG是高血压患者冠脉钙化的独立危险因素，并与冠脉钙化严重程度有关；在高血压伴冠脉钙化患者中，OPG与AngⅡ水平呈正相关。<br>ABSTRACT: Objective To evaluate the relationship between plasma osteoprotegerin (OPG) level and coronary artery calcification in patients with hypertension and the relationship between OPG and angiotensin Ⅱ (AngⅡ). Methods A total of 348 patients with hypertension were enrolled in this study. Coronary calcification was determined by 64-row coronary CT. Patients with hypertension were divided into coronary calcification group and non-coronary calcification group according to their coronary calcification score. We compared the clinical and laboratory indications of the two groups. The odds ratio (OR) value of risk factors for coronary calcification and the correlation coefficient between OPG and AngⅡ levels were calculated. Results The OPG and AngⅡ levels in patients with coronary calcification were higher than those in patients without coronary calcification (P<0.001). Multivariate logistic regression analysis showed that OPG level (OR 3.728, 95% CI 1.314-7.714) and AngⅡ level (OR 2.385, 95% CI 1.281-4.836) were both independent risk factors for coronary calcification (P<0.001). Moreover, OPG and AngⅡ levels were both correlated with the severity of coronary artery calcification. In patients with coronary calcification, OPG level was positively correlated with AngⅡ level (r=0.509, P<0.001), while in patients without coronary calcification, OPG level was not correlated with AngⅡ level (P>0.05). Conclusion OPG is an independent risk factor for coronary artery calcification in patients with hypertension and is related to the severity of coronary artery calcification. In hypertensive patients with coronary artery calcification, OPG and AngⅡ levels are positively correlated
%K 骨保护素
%K 高血压
%K 冠脉钙化
%K 血管紧张素Ⅱ<br>osteoprotegerin
%K hypertension
%K coronary artery calcification
%K angiotensinⅡ
%U http://yxxb.xjtu.edu.cn//oa/darticle.aspx?type=view&id=201906013