%0 Journal Article
%T Age-dependence of Some Trace Element Concentrations and Their Ratios in Human Prostatic Fluid - Age-dependence of Some Trace Element Concentrations and Their Ratios in Human Prostatic Fluid - Open Access Pub
%A Sofia Zaichick
%A Vladimir Zaichick
%J OAP | Home | Journal of Aging Research And Healthcare | Open Access Pub
%D 2018
%X The effect of age on Br, Fe, Rb, Sr, and Zn concentrations as well as on Zn/Br, Zn/Fe, Zn/Rb, and Zn/Sr content ratios in human prostatic fluid was investigated by 109Cd radionuclide-induced energy dispersive X-ray fluorescent microanalysis. Specimens of expressed prostatic fluid were obtained from 51 men (mean age 51 years, range 18-82 years) with apparently normal prostates using standard rectal massage procedure. Mean values (M ¡À S¦¥¦¬) for concentration of trace elements (mg¡¤L-1) in human prostate fluid were: Br 3.62¡À0.58, Fe 9.04¡À1.21, Rb 1.10¡À0.08, Sr 1.19¡À0.14, and Zn 573¡À28. Mean values for ratios of trace elements in human prostate fluid were: Zn/Br 523¡À103, Zn/Fe 105¡À16, Zn/Rb 661¡À63, and Zn/Sr 719¡À95. An age-related increase in Zn content and decrease in Br and Fe concentration was found. Moreover, the strongly pronounced increase in Zn/Br and Zn/Fe ratios was also observed. DOI10.14302/issn.2474-7785.jarh-19-2910 One of the main functions of prostate gland is a production, storage and excretion of prostatic fluid with extremely high concentration of Zn and some other trace elements (TE) and electrolytes. 1, 2 During ejaculation, the liquid that is released (sperm or ejaculate) has about 30% of its content contributed to by the prostatic fluid. Thus, the prostatic fluid very strong effects on the chemical element composition of sperm. Role of prostatic fluid is very important because it basically helps in increasing the chances of impregnation. There is a growing number of evidence indicating that advanced male age can affect fertility. 3, 4, 5 Numerous studies have investigated age-based alterations in semen traits, including such parameters as semen volume, sperm concentration, total sperm count, morphology, total motility, progressive motility and DNA fragmentation and some others. In most of these studies researches tried to determine whether age thresholds for parameters of semen quality exist. It was found that many measured parameters of ejaculates begin to change after 40 years of age. Forty years of age is also very significant thresholds for incidence of such prostatic diseases as being benign prostatic hypertrophy (BPH), and prostatic carcinoma (PCa). For example, it was reported that the risk of having PCa drastically increase with age, being three orders of magnitude higher for the age group 40¨C79 years than for those younger than 39 years. 6, 7 Experimental and epidemiological studies have reported the effects of some TE in ejaculate on male reproductive function. 8, 9, 10 Moreover, it was shown that Zn and Ca excess in prostatic
%U https://www.openaccesspub.org/jarh/article/1134