%0 Journal Article
%T Neuroscience Theories, Hypothesis and Approaches To ASD Physiopathology. A Review - Neuroscience Theories, Hypothesis and Approaches To ASD Physiopathology. A Review - Open Access Pub
%A Castej¨Žn OJ
%J OAP | Home | Journal of Neurological Research And Therapy | Open Access Pub
%D 2018
%X According to the results of our laboratory the theory of immune dysfunction, the theory on the genetic architecture of ASD, the disrupted cortical connectivity theory and the theory on the contribution of cerebellum to ASD have shown fundamental experimental evidences to support the core symptoms of the complex and enigmatic autism spectrum disorder. The following hypothesis, such as hypothesis of mirror neuron networks, on oxytocin and vasopressin in ASD, and the neurogenesis in the amygdala are interesting and stimulating approaches that deserve further basic and clinical research. DOI10.14302/issn.2470-5020.jnrt-19-2974 In a previous paper 1 (Castej¨Žn et al.,2019) we have reported a clinical study on 75 infant patients from 3 to 15 years with autism spectrum disorder in a developing country.These patients exhibited disconnected brain with social isolation (80%), hyperconnected children (5%), creative child, (Asperger syndrome) (10%), stereotypic movements of hands and body (10%), psicomotor retard (5%), behavioral changes such as aggresivity and autoagressivity (10%), crisis of tears (1%), separation anxiety (1%), mood disorders ( 3%), photofobia (1%), loss of weight, (1%), routinised patterns of though and fantastic thoughts (2%), language disorders such as delay in the onset of language or early vocalization, regressive changes of language, mutism, gestual language, escatologic language, digital language (5%), learning and memory deficit (10%). The following associated comorbidities: perinatal hypoxia, low weight at birth, behavioral abnormalities, anxiety, auto- and heteroaggressivity, language disorders, hiperphagia, learning and memory deficit, hearing disorders, mainly hiperacusia, Social isolation, cognitive deficit, sleeping disorders and parenteral abuse of child. Some non-nervous system comorbidities, such as pulmonary diseases and allergic reactions also were found. Some locomotor abnormalities as genus valgo and flat feet were also observed. The mothers exhibited the followings diseases during pregnancy: urinary infections, behavioral disturbances like anxiety, fobias, hyperactivity, toxoplasmosis and Zika virus infections, hyperemesis, oligohydramnios and lost of amniotic fluid, twin pregnancy, pre-eclampsia, aging placenta, cesarean, high blood pressure, maternal sepsis, diabetes, hepatic coma, hipotiroidism, viral hepatitis, parent obesity, and social problems, such as excessive work, low economy and poor social conditions, environmental contamination and labor and conjugal stress. We emphasized different phenotype subtypes of ASD
%U https://www.openaccesspub.org/jnrt/article/1152