%0 Journal Article
%T Effect of A High Fat and High Protein Diet On Exercise-induced Skeletal Muscle Hypertrophy in Rats - Effect of A High Fat and High Protein Diet On Exercise-induced Skeletal Muscle Hypertrophy in Rats - Open Access Pub
%A Koji Okamura
%A Naoya Nakai
%A Takako Fujii
%A Tomohiro Sonou
%J OAP | Home | International Journal of Nutrition | Open Access Pub
%D 2018
%X The skeletal muscle mass varies by race. Dietary habits over generations are a factor that influences the skeletal muscle mass, as well as genetic factors. Therefore, we investigated the effects of diets with different macronutrient contents on exercise-induced muscle hypertrophy in rats. Male 4-week-old Sprague¨CDawley rats were randomly divided into three groups: a normal-diet (N), high-protein diet (HP) and high-fat diet (HF) group. The food intake was manipulated to gain comparable body weight across the three groups. All rats were performed a climbing exercise training for 8 weeks. The final body weight and weight of the liver, kidneys and adipose tissues did not significantly differ among the groups. The flexor hallucis longus was significantly higher in the HF group than in the HP group. The total lipid content in the muscle was significantly higher in the HF group than in the N group, while it did not differ significantly between the HF and HP groups. There were no marked differences in the water or protein content in the muscle among the groups. The plasma amino acid concentration was significantly or tended to be lower in the HP group than in the HF or N group, except for the branched-chain amino acid concentration, which tended to be higher after ingesting the HP diet than other diets. These findings suggest that consuming an HP diet is not likely to facilitate exercise-induced muscle hypertrophy, partly due to the plasma amino acid imbalance induced by habitual HP diet consumption. DOI10.14302/issn.2379-7835.ijn-19-3011 Body composition reportedly varies by race, with Westerners being said to have more skeletal muscle mass than people of Asian descent 1, 2, 3. Genetic factors are likely primarily attributable to such variations, but dietary habits over the generations are also factors that influence the skeletal muscle mass. The Western diet is regarded as being high in protein and fat compared with the Asian diet. However, the protein-to-energy ratio does not differ significantly between the Western diet (12.2% in the US and 12.9% in France) and the Asian diet (11.1% in China and 13.1% in Japan), although the fat-to-energy ratio is higher in the Western diet (37.2% in the US and 41.8% in France) than in the Asian diet (29.5% in China and 28.8% in Japan) 4. Therefore, the greater skeletal muscle mass in Westerners may be associated with the higher fat ratio in their diet. Studies examining the effect of nutrition on muscle protein synthesis have focused on aspects such as the type 5 and ingested amount 6 of protein, as well as the effects of
%U https://www.openaccesspub.org/ijn/article/1180