%0 Journal Article
%T LC-MS analysis, antioxidant and alpha-glucosidase inhibitory activities of Centaurea papposa extracts
%J Bangladesh Journal of Pharmacology
%D 2019
%R https://doi.org/10.3329/bjp.v14i4.41246
%X This work aimed to ascertain the phenolic compounds and assess the antioxidant capacity and alpha-glucosidase inhibitory activity of Centaurea papposa extracts. Phenolic compounds were appraised using LC-MS technique. Moreover, antioxidant activity was investigated using DPPH, ABTS, CUPRAC and FRAP assays. In vitro alpha-glucosidase inhibitory effect was carried out. LC-MS analysis revealed the presence of 21 compounds among which 13 were phenolic acids, 6 flavonoids, 1 phenolic aldehyde and 1 benzopyrone. The ethyl acetate extract exhibited the highest activity in ferric reducing antioxidant power (FRAP) assay (IC50: 22.9 ¡À 2.8 ¦Ìg/mL). Nevertheless the n-butanol extract was the most active in cupric reducing antioxidant capacity assay (IC50: 3.1 ¡À 0.1 ¦Ìg/mL). A significant alpha-glucosidase inhibitory activity was displayed by dichloromethane extract (IC50: 227.6 ¡À 4.4 ¦Ìg/mL)
%U https://www.banglajol.info/index.php/BJP/article/view/41246