%0 Journal Article
%T Evaluation of Antioxidant and Cytotoxic Activities of Aerial Parts of Adiantum capillus-veneris L. Growing in Bangladesh
%A BK Sajeeb
%A Md Abdul Muhit
%A Sitesh C Bachar
%A Suvash Chandra Roy
%J Dhaka University Journal of Pharmaceutical Sciences
%D 2019
%R https://doi.org/10.3329/dujps.v18i2.43264
%X The present study evaluated the antioxidant and cytotoxic activities of methanolic extract of aerial parts of Adiantum capillus-veneris L. and its different solvent fractions. The in vitro antioxidant activity was assessed by using 2,2¡¯-diphenyl-1-picrylhydrazyl (DPPH) radicals. The analysis revealed that ethyl acetate soluble fraction had the highest DPPH radicals scavenging property with IC50 value of 1.05 ¦Ìg/ml as compared to positive control ascorbic acid (IC50 = 1.34 ¦Ìg/ml). In addition, ex vivo cytotoxicity assay of A. capillus-veneris L. extract and its different fractions were performed against HELA cells line where 5-Fluorouracil was used as positive control. The result demonstrated that ethyl acetate and n-hexane soluble fractions showed prominent cytotoxicity with IC50 value of 5.68 ¦Ìg/ml and 17.15 ¦Ìg/ml, respectively. The study affirmed that superior antioxidant and cytotoxic activities were shown by ethyl acetate soluble fraction of methanolic extract of aerial parts of A. capillus-veneris L. growing in Bangladesh which indicate the presence of bioactive phytoconstituents in the extractives
%U https://www.banglajol.info/index.php/JPharma/article/view/43264