%0 Journal Article
%T Allele-specific expression and alternative splicing in horseˇÁdonkey and cattleˇÁyak hybrids
%A Chen
%A Deng
%A Gao
%A Guang-Xian
%A Jing-Tao
%A Jun-Jie
%A Lei
%A Ming
%A Ni-Ni
%A Shan
%A Shao
%A Shen
%A Wang
%A Wei-Dong
%A Wei-Huang
%A Wen
%A Wen-Jing
%A Xu
%A Yu
%A Yue
%A Zhao
%A Zhou
%J Zoological Research
%D 2019
%X Divergence of gene expression and alternative splicing is a crucial driving force in the evolution of species; to date, however the molecular mechanism remains unclear. Hybrids of closely related species provide a suitable model to analyze allele-specific expression (ASE) and allele-specific alternative splicing (ASS). Analysis of ASE and ASS can uncover the differences in cis-regulatory elements between closely related species, while eliminating interference of trans-regulatory elements. Here, we provide a detailed characterization of ASE and ASS from 19 and 10 transcriptome datasets across five tissues from reciprocal-cross hybrids of horseˇÁdonkey (mule/hinny) and cattleˇÁyak (dzo), respectively. Results showed that 4.8%¨C8.7% and 10.8%¨C16.7% of genes exhibited ASE and ASS, respectively. Notably, lncRNAs and pseudogenes were more likely to show ASE than protein-coding genes. In addition, genes showing ASE and ASS in mule/hinny were found to be involved in the regulation of muscle strength, whereas those of dzo were involved in high-altitude adaptation. In conclusion, our study demonstrated that exploration of genes showing ASE and ASS in hybrids of closely related species is feasible for species evolution research
%U http://www.bioline.org.br/abstract?id=zr19030&lang=en