%0 Journal Article
%T Cholesterol lowering effects of Acacia nilotica subalata in Normal and Type 2 Diabetic Male Rats
%A A.
%A Bukachi
%A F. O. & Kiama
%A Niyodusenga
%A T. N.
%J Rwanda Medical Journal
%D 2019
%X OBJECTIVE: To investigate the effects of Acacia nilotica subalata on plasma lipids in normal and type 2 diabetic male rats. METHODS: Diabetes was induced in 18 out of 30 rats. The rats were in five groups: Group A normal control, Group B diabetic control, Group C diabetic rats treated with Acacia nilotica subalata, Group D normal rats treated with Acacia nilotica subalata and Group E diabetic rats receiving metformin. Blood glucose was measured with a glucometer. Lipids were assayed by colorimetric methods. Data were expressed as mean ¡À standard error of mean and analyzed using analysis of variance. Results were considered statistically significant if p < 0.05. RESULTS: Acacia nilotica subalata and metformin decreased total cholesterol in Groups C and E compared to diabetic control Group B (109.05 ¡À 9.134 and 90.69 ¡À 6.838 vs 153.89 ¡À 18. 829 mg/dl, p < 0.05). Acacia n. subalata and metformin in Groups C and E significantly decreased low density lipoproteins (LDL) compared to diabetic control Group B (59.62 ¡À 6.532 and 42.32 ¡À 4.844 vs 105.56 ¡À 15.14 mg/dl, p < 0.05). Acacia nilotica subalata leaf extract may be considered beneficial against hyperlipidemia induced by diabetes mellitus
%U http://www.bioline.org.br/abstract?id=rw19009&lang=en