%0 Journal Article
%T Zeolite as a Bone Bio-Modifier Carrier: An In-Vitro Study | Mousavi | Journal of Molecular Biology Research | CCSE
%A Azadeh Esmaeil Nejad
%A Behzad Houshmand
%A Erfan Shamsoddin
%A Mobina Mousavi
%A Mohammad Mehdi Golabgiran
%J Home | Journal of Molecular Biology Research | CCSE
%D 2019
%R 10.5539/jmbr.v9n1p126
%X Background: Zeolite is a microporous aluminosilicate compound which has been successfully used in tissue engineering. The effects of Zeolite on the morphology and functions of pre-osteoblastic MG-63 cells as new bone enhancer material is still unclear.

Methods: In this vitro experimental study, MTT and Alizarin red staining test were performed on six groups of MG-63 cells which differed in Zeolite (Z) concentration and the presence or absence of Alloplast extract (A). Group A: 0.1¦Ìg/mL Z+A, Group B: 0.1¦Ìg/mL Z without A, Group C: 0.2¦Ìg/mL Z+A, Group D: 0.2¦Ìg/mL Z without A, Group E: 0.3¦Ìg/mL Z+A, Group F: 0.3¦Ìg/mL Z without A. There were also three control groups as positive control, negative control, and Alloplast control based on each related test. The data were analyzed by SPSS 20 via one-way ANOVA and Welch test. (P<0.05).

Results: At 24 hours, results showed that solutions with 0.1¦Ìg/mL, 0.2¦Ìg/mL, and 0.3¦Ìg/mL Zeolite with or without Alloplast had significantly higher proliferation rates than positive control (distilled water) groups without Alloplast (p<0.001). At 72hours time point, the results showed significantly higher proliferation rates in the solutions with 0.1¦Ìg/mL, 0.2¦Ìg/mL, and 0.3¦Ìg/mL Zeolite with or without Alloplast compared to the positive control group without Alloplast (p<0.001).

Conclusions: Zeolite can increase proliferation of MG-63 cells without presence of Alloplast; It seems that combination of Zeolite with Alloplast maybe enhancing proliferation and function of MG-63 cells
%U http://www.ccsenet.org/journal/index.php/jmbr/article/view/0/41075