%0 Journal Article
%T Development and Validation of Stability Indicating RP-HPLC Method for Rivaroxaban and Its Impurities
%A Dipti Soni
%A Srinivasrao
%A Yashpalsinh N Girase
%J Journal of Biochemistry | Open Access Journal | High Impact Articles
%D 2018
%R http://dx.doi.org/10.15226/2376-4589/4/1/00127
%X Rivaroxaban is oxazolidinone derivative having anticoagulant activity. In literature few analytical methods are discuss about estimation of rivaroxaban; but rarer discussion is available for rivaroxaban impurity profile. The objective of this study is to develop and validate RP-HPLC method for the qualitative analysis of Rivaroxaban. The chromatographic separation was achieved on ZorbaxSB C18 (250 mmX4.6 mm,3.5 ¦Ì) HPLC column using buffer (0.02M mono basic potassium di hydrogen phosphate) and solvent mixture (acetonitrile: methanol mixture) ingradient programme. The developed methods were validated as per ICH guideline and found to be specific, precise, sensitive and robust. Keywords: Rivaroxaban; oxazolidinone derivative; Anticoagulant drug, RP-HPLC method; related substance; impurity profil
%U https://symbiosisonlinepublishing.com/biochemistry/biochemistry27.php