%0 Journal Article
%T A Study of EEG Alpha Wave Patterns in Patients with Cirrhosis and Minimal Hepatic Encephalopathy
%A Abhijit Swami
%A Bhaskar Kanti Nath
%A Riturag Thakuria
%A Tanuk K Biswas
%A Tanushree Debgupta
%J International Journal of Pancreatology | Journal of Gastroenterology and Liver Diseases
%D 2018
%R 10.15226/2374-815X/6/1/001118
%X Background: Minimal Hepatic Encephalopathy (MHE) is now increasingly described in patients with cirrhosis without any overt abnormalities on clinical examination. The diagnosis of MHE is based on multiple tests including a combination of paper and pencil tests, computerised tests and neurophysiological tests. Aim of the study: To study the alpha wave patterns in patients with MHE as this has been sparsely reported in the literature. Methods: The study included 70 diagnosed cases of cirrhosis and an equal number of age and sex matched control who were subjected to two paper and pencil tests ¨C NCT-A and DST along with EEG. Results and observations: Of the 70 patients included in the study, 56 (80%) was in CPC-A class. MHE was present in 52 (74.28%) cases of which 38 belonged to CPC-A class. In patients with MHE, alpha wave frequency (10.82 ¡À0.41Hz) was significantly lower than those in controls (11.52 ¡À 0.64 Hz) ( p< 0.05). Alpha wave amplitude was lower in MHE patients (35 ¡À 2.78 ¦ÌV) than in controls (48.18 ¡À 3.59 ¦ÌV) ( p < 0.05). The frequency and amplitude decreased with higher grades of CPC and higher NCT-A. No difference was noted in the pattern of other wave forms in EEG between patients with MHE and controls. Conclusion: A lower frequency and amplitude of alpha wave along with abnormal NCT-A can be predictive of MHE in cirrhosis
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