%0 Journal Article
%T Levels of electrolyte in cancer patients; a prospective study focusing on the Variations before and after therapy
%A Adnan Anwar
%A Ahsan Ali Siddiqui
%A Atika Shaheer
%A Muhammad Khurram Zia
%A Reena Kumari
%A Samahir Imtiaz
%A Sobia Fatima
%A Tayyaba Zubair
%J International Journal of Palliative Care | Open Access Journal of Palliative Medicine
%D 2018
%R 10.15226/2374-8362/5/4/00168
%X Introduction: Electrolyte derangement has been documented during cancer chemotherapy leading to the electrolyte imbalance. So, we conducted this study to evaluate the type and frequency of affected electrolytes. Objective: To assess frequency of electrolyte imbalances among cancer patients during Chemotherapy. Material and methods: This was an observational study and samples were collected using non-probability convenient sampling technique, which was conducted in a total duration of 1 year from 1st April 2016 to 30 March 2017 at Jinnah Postgraduate Medical Centre Karachi, Department of Oncology. Informed consent was obtained from patients after approval from ethical review institutional committee. Blood samples were collected for the assessment of the electrolyte levels with the help of analyzer. A total of 256 cancer patients were included, inclusion criteria include age range 18-70 years who received single or combination chemotherapy. Data analysis was done using SPSS version 20. Demographic variables like age, body surface area, weight and height were recorded. Paired t-test was used to assess the significance before and after treatment with p value of < 0.05. Results: The mean age of patients was 43.21¡À12.85 years while weight was 56.02¡À11.25 kg. In our study significant difference existed in electrolytes parameters. In our study potassium level before and after the chemotherapy was 3.99¡À0.25 mg/dl and 3.51¡À0.76 mg/dl (p< 0.001) respectively while sodium level before and after the chemotherapy was 139.66¡À2.35 mg/dl and 132.23¡À7.28mg/dl (p< 0.001) respectively. Urea level recorded was 19.952¡À4.46 mg/dl and 27.12¡À15.29 mg/dl (p< 0.001) respectively while recorded creatinine levels before and after chemotherapy was 0.60¡À0.21 and 0.84¡À0.44 mg/dl respectively (p< 0.001). Sodium, potassium, bicarbonate, magnesium, creatinine and urea levels show significant p values. Conclusion: Our study demonstrates that electrolyte imbalances are common during chemotherapy and monitoring should be done by medical oncologist so to avoid future morbidity and mortality. Key words: Electrolyte variations, Cancer patient
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