%0 Journal Article
%T Erythropoietin Response in Patients with Anaemia of Chronic Disorders
%A Alani S Akanmu
%A Christiana O Ukoli
%A Tinuade O Piwuna
%J Open Access Journal of Hematology impact factor| International Journal of Blood Disorders
%D 2018
%X Chronic disease conditions characterized by infection and intense inflammatory response abound in Sub-Saharan Africa and are very often complicated by anemia. Erythropoietin (EPO) is up regulated in response to anemic conditions. In Nigeria there is a dearth of public literature describing Anemia of Chronic Disease (ACD) and Erythropoietin levels in chronic diseases. The aim of the study was to determine the appropriateness of erythropoietin response to anemia observed in chronic disease. Methods: 215 participants were recruited from the wards and outpatient clinics, 125 cases (i.e. individuals with chronic diseases) and 90 controls consisting of individuals being seen for an annual or physical examination. Venous blood was collected for full blood counts, serum Iron (spectrophotometric), serum Ferritin (ELISA) and serum Erythropoietin (ELISA). Appropriateness of Erythropoietin response was determined by establishing an exponential relationship between erythropoietin levels and Hemoglobin (Hb) levels of controls (log EPO = 2.446 ¨C 0.11 x Hb g/l). Inappropriate Erythropoietin secretion was indicated by an observed/ predicted log (serum EPO) ratio of less than 0.8 (O/P< 0.8). Results: The result showed 72% of participants with chronic disease had anemia and 65.5% had anemia of chronic disease. Of the anemic participants, 33% had an Erythropoietin O/P ratio < 0.8, which corresponded with inappropriate Erythropoietin secretion. The mean circulating serum Erythropoietin level for control subjects was 13.1 ¡À10.1mu/l, significantly lower than that of subjects with chronic disease, 32.1¡À42.1m¦Ì/l (P =0.00). Correlation studies showed a significant negative relationship between Hemoglobin and Packed Cell Volume. Conclusion: The study showed that about two-thirds (65.5%) of the patients with anemia had Anemia of Chronic Disease, and a third showed evidence of diminished response endogenous Erythropoietin. Keywords: Anemia; Inappropriate Erythropoietin Response; Erythropoietin; Anemia of Chronic Disease; Chronic Disease; Iron; Ferriti
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