%0 Journal Article
%T Interferons, B Cells and Neutrophils: Innate and Adaptive Allies in Systemic Lupus Erythematosus
%A Alaa A A Mohamed
%A Tamer A Gheita
%J International Journal of Rheumatology | Rheumatology Journals Indexed in PubMed
%D 2018
%R 10.15226/2475-4676/3/2/00136
%X Systemic lupus erythematosus (SLE) is clinically and immunologically heterogeneous with variable organ involvement, severity and therapeutic responses. B cells are known as mediators of disease manifestations. Therefore, disease control is targeted by inhibiting proliferation and inducing apoptosis of B cells via conventional cytotoxic drugs or newly developing biologics. However, the outcome of therapy is sometimes heterogeneous which further attracts to understand other immune mechanisms influencing B cell functions such as interferons (IFNs) cytokines and the innate cells, neutrophils. Successful management of SLE requires an understanding of how these factors interact, taking into consideration the patients¡¯ variations in these factors which might confer heterogeneity in disease outcome. In this review, it will be focused on the existing data in literature on the mutual influence between interferons, B cells and neutrophils in disease pathogenesis and the clinical impact in disease assessment and their potential blocking. Keywords: Systemic Lupus Erythematosus; B Cells; Neutrophils; Cytokines and Inflammatory Mediators; Autoantigens and Autoantibodie
%U https://symbiosisonlinepublishing.com/rheumatology-arthritic-diseases/rheumatology-arthritic-diseases36.php