%0 Journal Article
%T Effect of Intracameral Dexamethasone Injection at Conclusion of Cataract Surgery on Macular Thickness in Diabetics
%A Ahmed Mahmoud Ragab
%A Amr Saad Bessa
%A Tamer Mousa Ibrahim
%J International Journal of Ophthalmology | Ophthalmology Journals Indexed in PubMed
%D 2017
%R 10.15226/2474-9249/2/2/00124
%X Context: To measure central macular thickness (CMT) in diabetic patients after instilling intracameral dexamethasone at the end of cataract surgery and compare this measure with control group. Design: Prospective case-control study. Participants: 100 eyes of 100 diabetic patients undergoing cataract extraction. Methods: 50 eyes received intracameral dexamethasone 0.4mg/0.1ml at the end of surgery and 50 eyes received sham treatment as a control group. The CMT was measured before, one month, and three months after the surgery Results: The mean CMT in was 261.32 ¡À 9.45¦Ìm in the dexamethasone injected group while in the control group was 275.76 ¡À 21.36¦Ìm (p < 0.05) at the end of first month postoperatively. At the end of the third postoperative month the mean CMT was 262.34 ¡À 10.77¦Ìm and 264.82 ¡À 9.73¦Ìm in the dexamethasone injected group and the control group, respectively, (p > 0.05). The mean Intraocular Pressure (IOP) in the dexamethasone injected eyes was 14.98 ¡À 2.82 and 15.1 ¡À 2.82mmHg before and at the end of the first month following the surgery, respectively, (p > 0.05). Conclusion: The CMT of eyes which received intracameral dexamethasone is significantly lower than the control group at the end of first postoperative month, suggesting a possible role of intracameral dexamethasone in suppressing the early inflammatory response that can be linked to post cataract surgery macular edema in diabetics. A non significant increase in the IOP has been observed in the dexamethasone injected group this makes intracameral dexamethasone injection a possible safe practice at the end of cataract extraction in diabetics. Keywords: Intracameral Dexamethasone; Cataract; Central Macular Thickness; Post- Cataract Macular Edema
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