%0 Journal Article
%T The Inhibitory Effect of Betanin on Adipogenesis in 3T3-L1 Adipocytes
%A Chin-Chen Chu
%A Heuy-Ling Chu
%A Jen-Yin Chen
%A Pin-Der Duh
%A Shih-Ying Chen
%J Journal of Food and Nutrition Research
%D 2019
%R 10.12691/jfnr-7-6-6
%X Betanin, a natural pigment that presents ubiquitously in plants, has been reported to show biological effects. However, not much is known on the effectiveness of betanin in regulating fat accumulation. Therefore, the aim of this study is to explore the inhibitory effect of betanin on adipogenesis in 3T3-L1 adipocytes and its mechanism action. The results show betanin significantly inhibited oil red O-stained material (OROSM) and triglyceride levels in 3T3-L1 adipocytes, indicating betanin inhibited lipid accumulation in 3T3-L1 adipocytes. In addition, the peroxisome proliferator¨Cactivated receptor ¦Ã (PPAR¦Ã) expression was significantly inhibited in the betanin-treated adipocytes, implying that betanin suppressed the cellular PPAR¦Ãexpression in 3T3-L1 adipocytes. Moreover, the suppression of lipid accumulation by betanin occurred by decreasing the gene expression of PPAR¦Ã, CCAAT-enhancer-binding protein ¦Á (C/EBP¦Á) and sterol regulatory element binding protein 1c (SREBP-1c). Taken together, these findings suggest betanin may be a mediator of adipocyte accumulation, leading to the inhibition of lipogenesis in 3T3-L1 adipocytes and betanin is therefore potentially useful for designing new antiadipogenic agent
%U http://www.sciepub.com/JFNR/abstract/10556