%0 Journal Article
%T Erythrocyte G6PD activity and GSH level as risk factors for vascular complications among type 2 diabetics in Osogbo, Nigeria
%A Olaniyan O.O
%A Osadolor H.B
%J Alexandria Journal of Medicine
%D 2019
%R https://doi.org/10.1080/20905068.2019.1688986
%X ABSTRACT Background: Glucose-6-phosphate dehydrogenase (G6PD) catalyzes the oxidation of glucose-6-phosphate (G6P) to produce nicotine-adenosine-dinucleotide phosphate coenzyme (NADPH), a major defense against oxidative damage in erythrocytes. This study aims at evaluating enzymatic G6PD activity and erythrocyte glutathione (eGSH) as a biomarker of vascular complications among type 2 diabetics. Methods: Fasting Plasma glucose (FPG), glycated hemoglobin (HbA1c), erythrocyte G6PD (eG6PD) activity and erythrocyte GSH (eGSH) level were determined along with measured anthropometrics in 120 known type 2 diabetics (comprising 60 diabetics without vascular complications and 60 diabetics with vascular complications) and 50 age and sex matched apparently healthy non diabetes individuals recruited for this study. Results: Result revealed significant reduced eG6PD activity and eGSH levels in type 2 diabetics especially among those with vascular complications as compared to subjects without diabetes, with a slight correlation between eGSH level and eG6PD activity of diabetics with vascular complications. Conclusion: The study, therefore, advocates measurement of G6PD activity and GSH level in type 2 diabetics to properly monitor the progress of the disease
%U https://www.tandfonline.com/doi/full/10.1080/20905068.2019.1688986