%0 Journal Article
%T Effects of Danshen tablets on pharmacokinetics of amlodipine in rats
%A Haixia Zhang
%A Hangao Li
%A Xichun Guo
%A Xiuyuan Han
%A Yiqing Li
%J Pharmaceutical Biology
%D 2019
%R https://doi.org/10.1080/13880209.2019.1604768
%X Abstract Context: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with amlodipine (ALDP) for treating coronary heart disease. Objective: This study investigated the effects of DST on the pharmacokinetics of ALDP and the potential mechanism. Materials and methods: The pharmacokinetics of ALDP (1£¿mg/kg) in male Sprague¨CDawley rats (n£¿=£¿6), with or without pretreatment of DST (100£¿mg/kg for 7£¿d), were investigated using LC-MS/MS. The effects of DST on the metabolic stability of ALDP were also investigated using rat liver microsomes (RLM). Results: The results indicated that Cmax (16.25£¿¡À£¿2.65 vs. 22.79£¿¡À£¿2.35£¿ng/ml), AUC(0¨Ct) (222.87£¿¡À£¿59.95 vs. 468.32£¿¡À£¿69.87£¿n£¿gh/ml), and t1/2 (10.60£¿¡À£¿1.05 vs. 14.15£¿¡À£¿1.59£¿h) decreased significantly when DST and ALDP were co-administered, which suggested that DST might influence the pharmacokinetic behaviour of ALDP when they are co-administered. The metabolic stability of ALDP was also decreased (23.6£¿¡À£¿4.7 vs. 38.9£¿¡À£¿5.2) with the pretreatment of DST. Discussion and conclusions: This study indicated that DST could accelerate the metabolism of ALDP in RLM and change the pharmacokinetic behaviours of ALDP. Accordingly, these results showed that the herb¨Cdrug interaction between DST and ALDP might occur when they were co-administered. Therefore, the clinical dose of ALDP should be increased when DST and ALDP are co-administered
%U https://www.tandfonline.com/doi/full/10.1080/13880209.2019.1604768