%0 Journal Article
%T Relationship between genetic polymorphism of MTHFR C677T and lower extremities deep venous thrombosis
%A Jiasheng Xu
%A Kexin Li
%A Weimin Zhou
%J Hematology
%D 2019
%R https://doi.org/10.1080/10245332.2018.1526440
%X ABSTRACT Objective: To investigate the association between the polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and the formation of lower extremities deep venous thrombosis, and to evaluate the etiology of deep venous thrombosis. Methods: Polymorphisms of the 677th site C/T in MTHFR gene for 101 patients with lower extremities deep venous thrombosis (DVT group) and 120 healthy subjects (control group) were detected by polymerase chain reaction with sequence-specific primers. Genotype and allelic frequencies were compared between the two groups. Results: Genotype frequencies of CC, CT and TT in MTHFR C677£¿T were 41.58, 25.74 and 32.67% in DVT group, and 58.33, 23.33 and 18.33% in control group, respectively. There was a significant difference in TT genotype frequency between the two groups (P <0.05). Conclusion: The frequency of MTHFR 677TT genotype may be correlated with the morbility of DVT
%U https://www.tandfonline.com/doi/full/10.1080/10245332.2018.1526440