%0 Journal Article
%T Risk factors for venous thromboembolism (VTE) recurrences in Thai patients without cancer
%A Panchalee Satpanich
%A Ponlapat Rojnuckarin
%J Hematology
%D 2019
%R https://doi.org/10.1080/10245332.2018.1535535
%X ABSTRACT Introduction: Studies in Western countries show that VTE recurrent rates are lower in the presence of a transient provoking factor, older age, female sex and/or hormonal use, while thrombophilia (factor V Leiden or prothrombin mutation) has no predictive role. This study aimed to determine the incidence and risk factors of recurrent VTE in Asian patients. Method: This is a retrospective cohort study in adult VTE patients who were diagnosed during 2004¨C2014, had no active cancer and followed-up for at least 1 year. Results: There were 198 patients. The mean age was 58.2£¿¡À£¿17.6 years and 68.2% were female. The diagnoses were deep vein thrombosis (56%), pulmonary embolism (32%) or both (12%). They were provoked by major surgery in 21.7%. Thrombophilia (antiphospholipid syndrome or protein C or protein S deficiency) was found in 11.6%. The recurrent rate during the median follow-up time of 52 months was 2.2 (95% confidence interval [CI] 1.46¨C3.31) per 100 patient-years. Presence of thrombophilia was independently associated with recurrences with the adjusted hazard ratio (aHR) of 3.52 (95% CI 1.32¨C9.42, p£¿=£¿0.01). There were 144 patients who discontinued anticoagulants. During the median time of 55 months after stopping anticoagulants, the recurrent rate was 4.3 per 100 patient-years. Thrombophilia was associated with recurrences with aHR of 4.00 (95% CI 1.42¨C11.31, p£¿=£¿0.01), while male sex, younger age, provoking conditions and hormone use showed no significant association. Conclusion: VTE recurrent rate in Asians is comparable to Caucasians, but thrombophilia is the strongest risk factor
%U https://www.tandfonline.com/doi/full/10.1080/10245332.2018.1535535