%0 Journal Article
%T Carbazole scaffolds in cancer therapy: a review from 2012 to 2018
%A Anthony Pr
%A Marc Le Borgne
%A Nicolas Bedel
%A P£¿l Rongved
%A Samar Issa
%A Sa£¿d Yous
%A Zouhair Bouaziz
%A ina
%J Journal of Enzyme Inhibition and Medicinal Chemistry
%D 2019
%R https://doi.org/10.1080/14756366.2019.1640692
%X Abstract For over half a century, the carbazole skeleton has been the key structural motif of many biologically active compounds including natural and synthetic products. Carbazoles have taken an important part in all the existing anti-cancer drugs because of their discovery from a large variety of organisms, including bacteria, fungi, plants, and animals. In this article, we specifically explored the literature from 2012 to 2018 on the anti-tumour activities reported to carbazole derivatives and we have critically collected the most significant data. The most described carbazole anti-tumour agents were classified according to their structure, starting from the tricyclic¨Ccarbazole motif to fused tetra-, penta-, hexa- and heptacyclic carbazoles. To date, three derivatives are available on the market and approved in cancer therapy
%U https://www.tandfonline.com/doi/full/10.1080/14756366.2019.1640692