%0 Journal Article
%T Cancer cell growth inhibition by aroylhydrazone derivatives
%A Anelia Balacheva
%A Darko Kontrec
%A Ivan Iliev
%A Maya Georgieva
%A Nives Gali£¿
%A Roumiana Detcheva
%A Tamara Pajpanova
%J Biotechnology & Biotechnological Equipment
%D 2019
%R https://doi.org/10.1080/13102818.2019.1608302
%X Abstract Hydrazones have versatile properties that make them promising for a range of possible applications. In this study, we examined a library of 17 aroylhydrazones derived from nicotinic acid hydrazide (1-12) and isonicotinic acid hydrazide (A-E) created by us for their biological activity. The antiproliferative activity of the compounds was investigated on non-tumour MCF-10A cells and cancer cell lines, MCF-7 and MDA-MB-231. Four compounds were selected as most active in cell growth inhibition of the tumour cell lines. These compounds, 5, 11, C and E, were tested on four additional cell lines: non-tumour BJ and cancer cell lines, HeLa, HepG2 and HT-29. Compounds 5 and E exhibited the highest selectivity index on cancer cell lines MDA-MB-231, HeLa and HepG2. High selectivity to MCF-7 cells was demonstrated with compound 5. Compound C was very selective to HepG2 cells as well as to MDA-MB-231 but to a lesser degree. Compound 11 showed selectivity against MDA-MB-231. The obtained results allow assessing the structure¨Cactivity relationship of the compounds and provide insight into the further development of this group of aroylhydrazones as more potent and selective anti-neoplastic agents
%U https://www.tandfonline.com/doi/full/10.1080/13102818.2019.1608302