%0 Journal Article
%T Modified-FOLFIRINOX combined with deep regional hyperthermia in pancreatic cancer: a retrospective study in Chinese patients
%A Bing Wang
%A Danyi Zhao
%A Hongmei He
%A Jinghua Sun
%A Lingling Xu
%A Meng He
%A Shanling Ren
%A Tao Wu
%A Yang Zhang
%A Yu Shang
%J International Journal of Hyperthermia
%D 2019
%R https://doi.org/10.1080/02656736.2019.1579371
%X Abstract Background: FOLFIRINOX chemotherapy displays significant survival improvements in patients with pancreatic cancer. However, toxicities have hampered enthusiasm for the use of FOLFIRINOX in full dose. In order to increase the tolerability, many researchers focused on the modification of FOLFIRINOX. On the other hand, hyperthermia (HT) has been considered as an effective ancillary treatment for cancer therapy. Up to now, there is no report evaluating combining deep regional hyperthermia (DRHT) with modified-FOLFIRINOX for pancreatic cancer patients. Methods: In this study, we conducted a retrospective review of pancreatic cancer patients treated with the combination of new form modified-FOLFIRINOX and DRHT (BSD2000). Patients underwent chemotherapy that included low-dose irinotecan (70每130ˋmg/m2), oxaliplatin (65每70ˋmg/m2) on day 1 and 5-FU (2400ˋmg/m2 as a 46ˋh continuous infusion, no bolus) or capecitabine (CAP) (1000ˋmg/m2 twice daily on days 1每10) or tegafur, gimeracil and oteracil potassium (TS-1) (80每120ˋmg/d twice daily on days 1每10), 2-week schedule. Generally, DRHT treatment was performed weekly, 45ˋmin for each time during chemotherapy. Results: The patients receiving mFOLFIRINOX as the first line chemotherapy combining with DRHT, obtained an improvement in OS and PFS, 17 months (95% CI 1.97每32.03 months) and 4 months (95% CI 0每8.29 months) respectively. Overall, this combination regimen was safe; 17.6% patients suffered from grade 3/4 toxicities. Conclusions: In conclusion, we conducted a retrospective study combining mFOLFIRINOX and DRHT, which was well tolerated. The efficacy in the treatment of pancreatic cancer was encouraging, but further studies would be required to prove its merit, compared with conventional treatment
%U https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1579371