%0 Journal Article
%T Ultrasound-guided percutaneous microwave ablation versus surgical resection for recurrent intrahepatic cholangiocarcinoma: intermediate-term results
%A Chao Du
%A Chuanjun Xu
%A Jinlong Tong
%A Lei Li
%A Lixin Yang
%A Wei Xu
%A Yongxiang Yi
%J International Journal of Hyperthermia
%D 2019
%R https://doi.org/10.1080/02656736.2019.1571247
%X Abstract Objective: The aims of this study were to compare the clinical outcomes between ultrasound-guided percutaneous microwave ablation (US-PMWA) and surgical resection (SR) in patients with recurrent intrahepatic cholangiocarcinoma (ICC) and to identify the prognostic factors associated with the two treatment methods. Methods: This retrospective study was institutional review board approved. A total of 121 patients (102 men and 19 women) with 136 ICCs after hepatectomy from April 2011 to January 2017 were reviewed. Fifty-six patients underwent US-PMWA and 65 patients underwent SR. Survival, recurrence and liver function were compared between the two groups. Effect of changes in key parameters [i.e., overall survival (OS) and recurrence-free survival (RFS)] was statistically analyzed with the log-rank test. Univariate and multivariate analysis were performed on clinicopathological variables to identify factors affecting long-term outcome. Results: The OS and RFS after MWA were comparable to that of SR (p£¿=£¿.405, and p£¿=£¿.589, respectively). Estimated 5-year OS rates were 23.7% after MWA and 21.8% after SR; for RFS, estimated 3-year RFS rates were 33.1% after MWA and 30.6% after SR. Major complication rates in SR group were higher than that in MWA (p£¿<£¿.001) (SR, 13.8% vs. MWA, 5.3%). Multivariate analysis showed tumor number (p£¿=£¿.012), ALBI grade (p£¿=£¿.007), and metastasis (p£¿=£¿.016), may become OS rate predictors. Conclusions: US-PMWA had comparable oncologic outcomes with SR and could be a safe and effective treatment for recurrent ICC after hepatectomy
%U https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1571247