%0 Journal Article
%T US-guided microwave ablation for secondary hyperparathyroidism in patients after renal transplantation: a pilot study
%A Chao An
%A Lili Peng
%A Mingan Yu
%A Xin Li
%J International Journal of Hyperthermia
%D 2019
%R https://doi.org/10.1080/02656736.2019.1566580
%X Abstract Objective: To assess the safety and efficacy of ultrasound-guided microwave ablation (MWA) in the treatment of patients who develop secondary hyperparathyroidism (SHPT) after renal transplantation (RT). Methods: In total, nine patients, each with symptomatic SHPT caused by RT and at least one enlarged parathyroid gland, underwent MWA via hydrodissection. Intact parathyroid hormone (i-PTH), serum calcium, serum phosphorus, creatinine and blood urea nitrogen concentrations, before and after MWA, were assessed and compared. Results: Complete ablation was achieved in all patients for a total of 14 ablated parathyroid glands. The mean follow-up time was 17.2£¿¡À£¿1.7£¿months post-operation. The mean maximum diameter of the parathyroid glands was 1.3£¿¡À£¿0.4£¿cm (range: 0.4¨C2.0£¿cm). The ablation power implemented was 30£¿W and the mean time for each parathyroid gland to achieve complete ablation was 287.5£¿¡À£¿83.4£¿s. The mean i-PTH, serum calcium and phosphorus concentrations at one day post-MWA (69.6£¿pg/mL, 2.23£¿¡À£¿0.29£¿mmol/L, 1.2 2£¿¡À£¿0.48£¿mmol/L, respectively) were significantly lower than those before MWA (780.0£¿pg/mL, 2.62£¿¡À£¿0.32£¿mmol/L, 1.39£¿¡À£¿0.61£¿mmol/L, respectively; p£¿<£¿.01), whereas the creatinine and blood urea nitrogen concentrations before and after MWA did not differ significantly from each other (p£¿>£¿.05). No significant differences were found between the biomarker concentrations observed at one day post-MWA and at the follow-ups (p£¿>£¿.05). No major operation-related complications occurred. Conclusion: Ultrasound-guided MWA is a safe and effective technique for destroying parathyroid gland tissue in patients who develop SHPT after RT and its clinical effects are long-lasting
%U https://www.tandfonline.com/doi/full/10.1080/02656736.2019.1566580