%0 Journal Article
%T The value of KRAS gene status in predicting local tumor progression of colorectal liver metastases following radiofrequency ablation
%A Bin-bin Jiang
%A Kun Yan
%A Min-hua Chen
%A Shan-shan Yin
%A Wei Wu
%A Wei Yang
%A Zhong-yi Zhang
%J International Journal of Hyperthermia
%D 2019
%R https://doi.org/10.1080/02656736.2018.1556818
%X Abstract Purpose: We investigated the relationships between KRAS gene status and local tumor progression (LTP) of colorectal liver metastases (CLMs) after treatment with percutaneous ultrasound-guided radiofrequency ablation (RFA). Materials and methods: Clinical and imaging data from 76 patients (154 lesions) with CLM who underwent percutaneous ultrasound-guided RFA and had KRAS gene test results between January 2012 and June 2016 were analyzed. The average lesion size was 2.3£¿¡À£¿1.0£¿cm (range 0.9¨C5.7£¿cm); 38 cases (82 lesions) had wild-type KRAS, and 38 cases (72 lesions) had KRAS mutations. Results: The technique effectiveness was 98.1% (151/154), and the LTP rate was 18.2% (28/154) after RFA, which was performed between January 2012 and November 2017. The mean and median follow-up were 32.7£¿¡À£¿2.5 and 32.0£¿¡À£¿2.6 months (range 1¨C70 months), respectively. Cumulative LTP rates at 6 months and 1, 2 and 3 years post-RFA for all patients were 7.4, 14.5, 17.8 and 19.2%, respectively. The LTP rate for patients with mutant KRAS (27.8% [20/72]) was significantly higher than that in patients with wild-type KRAS (9.8% [8/82]; p£¿=£¿.004). The cumulative LTP rates at 6 months and 1, 2 and 3 years post-RFA were 4.0, 11.1, 11.1 and 11.1%, respectively, for patients with wild-type KRAS and 11.2, 18.4, 25.2 and 36.2%, respectively, for patient with mutant KRAS (p£¿=£¿.011). Univariate (p£¿=£¿.011) and multivariate analyses (p£¿=£¿.005) showed that KRAS genotype in liver metastases was predictive of LTP. Multivariate analysis also showed that ablation margin size (p< .001) and modified clinical risk score (CRS; p£¿=£¿.033) were independent prognostic factors for LTP. Conclusions: KRAS gene status of liver metastatic lesions was associated with LTP rates after RFA of CLM. Ablation margin size and modified CRS were also independent prognostic factors for LTP
%U https://www.tandfonline.com/doi/full/10.1080/02656736.2018.1556818