%0 Journal Article
%T The influence of MTHFR genetic polymorphisms on adverse reactions after methotrexate in patients with hematological malignancies: a meta-analysis
%A Hongtao Xiao
%A Pingli Yao
%A Rong Zhang
%A Rongsheng Tong
%A Xia He
%J Hematology
%D 2019
%R https://doi.org/10.1080/10245332.2018.1500750
%X ABSTRACT Objectives: The effect of methotrexate (MTX)-related adverse reaction on hematologic neoplasms patients is controversial. We performed this meta-analysis to assess the association between methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism and the adverse reaction after MTX using. Methods: We searched for qualified studies according to PubMed, the Cochrane Library, and the Web of Science. The meta-analysis was performed by Review Manager 5.3. The analysis was conducted to compare risk ratios (RRs) with the corresponding 95% confidence interval (95% CI) to evaluate the relationship between different toxicity reactions and the genotype of MTHFR. Results: We included 17 studies which satisfied with the criteria in this meta-analysis. The results of our statistical analysis showed that no significant correlation between MTHFR C677T/A1298C genetic polymorphism and patients¡¯ toxicity or the relapse and survival associated with MTX chemotherapy (P£¿>£¿.05). But we observed that a tendency toward increased risk of hepatotoxicity was also present for acute lymphoblastic leukemia in the mutation model (CT/TT vs. CC: RR: 1.92, 95% CI: 1.01¨C3.67; P£¿=£¿.05). Conclusion: The polymorphism of MTHFR C677T/A1298C may not be an important indicator for the accurate detection of side effects of chemotherapy after using MTX. More relative research is needed
%U https://www.tandfonline.com/doi/full/10.1080/10245332.2018.1500750