%0 Journal Article
%T Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography
%A AlGhalya A. Alumairi
%A Humoud Al-Dhuhli
%A Moez Hassan
%A Murtadha Al-Khabori
%A Said A. Al-Busafi
%A Sara Al-Rahbi
%A Shahina Daar
%A Umaima Al-Ajmi
%J Hematology
%D 2019
%R https://doi.org/10.1080/10245332.2018.1540518
%X ABSTRACT Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326£¿¦Ìg/L and 6.7£¿mg/g£¿dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p£¿=£¿.0373). Additionally, the 5yrSF (p£¿=£¿.00661), the LIC (p£¿=£¿.0225) and the lowest LIC of the previous 5 years (p£¿=£¿.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p£¿=£¿.0035) and gender (p£¿=£¿.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM
%U https://www.tandfonline.com/doi/full/10.1080/10245332.2018.1540518