%0 Journal Article
%T A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells
%A Geun Eog Ji
%A Hyun Ju You
%A Seockmo Ku
%A Yunju Jeong
%J CyTA - Journal of Food
%D 2019
%R https://doi.org/10.1080/19476337.2019.1607562
%X ABSTRACT We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 ¦ÌM, respectively, of 20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2 were administered to the colon cancer cell line HT-29, only the S-type ginsenoside Rh2 lowered cancer cell viability. Similarly, when the same experiment was conducted on cancer cells with different levels of ginsenoside treatments (20, 40, 60, and 80 ¦ÌM), cancer cell viability was decreased in a dose-dependent manner only in the 20(S)-ginsenoside Rh2 treatment groups. Cytotoxicity of cancer cells was observed only in the S form-treated group when cellular response and growth pattern were analyzed via real-time cellular analysis. These findings suggest that the anti-tumor effect of ginsenoside Rh2 on colon cancer cells is S-form selective
%U https://www.tandfonline.com/doi/full/10.1080/19476337.2019.1607562