%0 Journal Article
%T Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model
%A Guohua Wei
%A He Tian
%A Liang Zhao
%A Mengdie Li
%A Tao Wang
%A Yijie Shi
%J Artificial Cells, Nanomedicine, and Biotechnology
%D 2019
%R https://doi.org/10.1080/21691401.2019.1669617
%X Abstract Chronic, subclinical inflammation was often observed in the diabetic wound area, causing inadequate and delayed wound-healing effects by failing to initiate cell migration, proliferation, and extracellular matrix deposition. Therefore, we presented macrophage-derived exosomes (Exos) and explored their potential for inhibiting inflammation and accelerating diabetic wound healing in a skin defect, diabetic rat model. A thorough investigation demonstrated that Exos exerted anti-inflammatory effects by inhibiting the secretion of pro-inflammatory enzymes and cytokines. Furthermore, they accelerated the wound-healing process by inducing endothelial cell proliferation and migration to improve angiogenesis and re-epithelialization in diabetic wounds
%U https://www.tandfonline.com/doi/full/10.1080/21691401.2019.1669617