%0 Journal Article
%T Novel multifunctional triple folic acid, biotin and CD44 targeting pH-sensitive nano-actiniaes for breast cancer combinational therapy
%A Bingjie Wang
%A Chunjing Guo
%A Daquan Chen
%A Mengna Liu
%A Xiaoya Hou
%A Ziting Cheng
%J Drug Delivery
%D 2019
%R https://doi.org/10.1080/10717544.2019.1669734
%X Abstract In this study, novel multifunctional folic acid, biotin, and CD44 receptors targeted and pH-sensitive ¡°nano-actiniaes¡± were fabricated with icariin (ICA) and curcumin (Cur) as loaded model drugs for breast cancer therapy. The newly synthesized polymer oligomeric hyaluronic acid-hydrazone bond-folic acid-biotin (Bio-oHA-Hyd-FA) was characterized by 1H NMR spectrogram (proton nuclear magnetic resonance). The obtained drug carrier Bio-oHA-Hyd-FA self-assembled into nanomicelles, named as ¡°nano-actiniaes¡±, in aqueous media with hydrodynamic diameter of 162.7£¿¡À£¿5£¿nm. The size, surface zeta potential, and morphology of the ¡°nano-actiniaes¡± were observed via TEM. The in vitro release experiment indicated that much more encapsulated icariin (ICA) and curcumin (Cur) were released from the Bio-oHA-Hyd-FA micelles (nano-actiniaes) in the acidic environment. Additionally, the cytotoxicity research demonstrated that the Bio-oHA-Hyd-FA carrier material was completely nontoxic, and the ICA&Cur ¡°nano-actiniaes¡± had greater cytotoxicity compared with other control groups. In addition, the ¡°nano-actiniaes¡± were found to significantly inhibit cancer cell invasion by Transwell assay. Moreover, in vivo evaluation of anti-tumor effect illustrated that the ICA and Cur ¡°nano-actiniaes¡± possessed inhibitory effect on tumors. Consequently, the multi-targeted pH-sensitive ¡°nano-actiniaes¡± can realize significant tumor targeting and effectively inhibit tumor growth
%U https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1669734