%0 Journal Article
%T Study on preparation, characterization and multidrug resistance reversal of red blood cell membrane-camouflaged tetrandrine-loaded PLGA nanoparticles
%A Enge Xu
%A Jieyu Chen
%A Jing Su
%A Mingfeng Qiu
%A Pengcheng Guo
%A Siyu Liu
%A Xiao Que
%A Zul Kamal
%J Drug Delivery
%D 2019
%R https://doi.org/10.1080/10717544.2019.1573861
%X Abstract The multidrug resistance in tumor (MDR) is a major barrier to efficient cancer therapy. Modern pharmacological studies have proven that tetrandrine (TET) has great potential in reversing MDR. However, it has a series of medication problems in clinic such as poor water solubility, low oral bioavailability and short half-life in vivo. Aiming at the above problems, red blood cell membrane-camouflaged TET-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (RPTNs) had been developed. The RPTNs had spherical shell-core double layer structure with average particle size of 164.1£¿¡À£¿1.65£¿nm and encapsulation efficiency of 84.1%£¿¡À£¿0.41%. Compared with TET-PLGA nanoparticles (PTNs), the RPTNs reduced RAW 264.7 macrophages¡¯ swallowing by 32% due to its retention of natural membrane proteins. The cumulative drug release of RPTNs was 81.88% within 120£¿h. And pharmacokinetic study showed that the blood half-life of RPTNs was 19.38£¿h, which was 2.95 times of free drug. When RPTNs of 2£¿¦Ìg/mL TET were administered in combination with adriamycin (ADR), significant MDR reversal effect was observed in drug-resistant cells MCF-7/ADR. In a word, the RPTNs hold potential to improve its efficacy and broaden its clinical application
%U https://www.tandfonline.com/doi/full/10.1080/10717544.2019.1573861