%0 Journal Article
%T TIMP-2 inhibits metastasis and predicts prognosis of colorectal cancer via regulating MMP-9
%A Dan Li
%A Jianliang Deng
%A Li Tao
%A Liangliang Xiang
%A Mengying Lv
%A Sunagawa Masatara
%A Tengyang Ni
%A Weimin Wang
%A Xiancheng Gu
%A Yan Zhou
%A Yanqing Liu
%J Cell Adhesion & Migration
%D 2019
%R https://doi.org/10.1080/19336918.2019.1639303
%X ABSTRACT Colorectal cancer has a common cause of morbidity and mortality. Therefore, it is urgent to detect reliable biomarkers to predict prognosis in CRC. Here, we determined the expression of TIMP-2 and MMP-9 in a CRC tissue microarray by immunohistochemistry. We found that lower TIMP-2 or/and higher MMP-9 expression in cancer tissues was correlated with poorer overall survival (OS). TIMP-2 or MMP-9 expression was independent prognostic factors for CRC. Furthermore, TIMP-2 and MMP-9 expression had a synergistic role as efficient prognostic indicators for CRC patients. In vitro and in vivo, TIMP-2 could inhibit HCT 116 cells invasion and migration by regulating MMP-9. In sum, a combined expression of TIMP-2 and MMP-9 as efficient prognostic indicators was found for the first time
%U https://www.tandfonline.com/doi/full/10.1080/19336918.2019.1639303