%0 Journal Article
%T Evaluation of serum C-reactive protein and high mobility group box 1 concentrations in 22 dogs with acute pancreatitis: a pilot study
%A Byeong-Teck Kang
%A Hakhyun Kim
%A Hyung-Jin Kim
%A Ji-Houn Kang
%A Mhan-Pyo Yang
%J Veterinary Quarterly
%D 2019
%R https://doi.org/10.1080/01652176.2019.1655178
%X Abstract Background: High mobility group box 1 (HMGB1) is an important mediator of systemic inflammatory response syndrome (SIRS) in humans with severe acute pancreatitis (AP), but there is little information regarding its role in dogs. Aim: To compare the serum concentrations of C-reactive protein (CRP) and HMGB1 in healthy dogs and those with AP with or without SIRS. Methods: The study included 22 dogs with AP and 20 healthy dogs. CRP and HMGB1 were assessed by ELISA. Statistical analyses were conducted by non-parametric tests. Results: Median (interquartile range) serum CRP and HMGB1 concentrations were significantly (Pˋ<ˋ0.05) higher in dogs with AP [60.56 (14.50每140.10) 米g/mL and 0.35 (0.03每1.12) ng/mL, respectively] than in healthy dogs [2.23 (1.75每5.14) 米g/mL and 0.02 (0.01每0.05) ng/mL, respectively]. After the recommended treatments for AP, serum CRP concentration in AP dogs significantly decreased, but that of HMGB1 in AP dogs significantly increased. There was also a significant difference in median serum HMGB1 concentration between AP dogs with and without SIRS. The use of serum HMGB1 concentration of 0.35ˋng/mL to distinguish AP dogs with and without SIRS was associated with a sensitivity of 87.5% and a specificity of 71.5%. A positive correlation was identified between HMGB1 and clinical severity of AP. All AP dogs had a positive outcome during hospitalization [6.0 (1.5每6.0) days]. Conclusion: Results indicate that HMGB1 might be a useful biomarker for the progression of AP and may play a role in progression of AP into SIRS in dogs
%U https://www.tandfonline.com/doi/full/10.1080/01652176.2019.1655178