%0 Journal Article
%T Serum alkaline phosphatase levels correlate with long-term mortality solely in peritoneal dialysis patients with residual renal function
%A Caixia Yan
%A Jun Xiao
%A Li Zhang
%A Panlin Qiu
%A Qinglan Hu
%A Qinkai Chen
%A Siyi Liu
%A Xiaojiang Zhan
%A Xin Wei
%A Yanbing Chen
%A Yu Wang
%A Yuting Yang
%J Renal Failure
%D 2019
%R https://doi.org/10.1080/0886022X.2019.1646662
%X Abstract Introduction: Increased serum alkaline phosphatase (ALP) is predictive of a higher mortality in patients with end-stage renal disease. However, it remains unknown whether residual renal function (RRF) influences the outcome-association of serum ALP among peritoneal dialysis (PD) patients. Methods: A total of 650 incident PD patients receiving PD catheter implantation in an institute between 1 November 2005 and 28 February 2017 were retrospectively enrolled. These patients were divided into groups with and without RRF (RRF and non-RRF groups) and those with serum ALP levels in tertiles. The Kaplan每Meier method and multivariate Cox proportional hazard models were used to analyze their outcomes based on RRF and serum ALP levels. Results: These 650 patients had a mean age of 49.4ˋ㊣ˋ14.0 years old, their median ALP level was 74ˋU/L (interquartile range (IQR): 59每98). After 28-month (IQR: 14每41) follow-up, 80 patients in RRF group and 40 patients in non-RRF group died. PD patients with the highest serum ALP tertile had significant lower survival (pˋ=ˋ.014), when compared to other patients in the RRF group. However, this relationship was not observed in patients in the non-RRF group. After multivariate adjustment, in the RRF group, patients with the highest ALP tertile had a significantly higher risk of mortality (hazard ratio (HR): 2.26, 95% confidence interval (CI): 1.06每4.82, pˋ=ˋ.034). Each 10-U/L increase in ALP level was associated with a 4% (HR: 1.04, 95% CI: 1.00每1.08, pˋ=ˋ.045) higher mortality risk. Conclusions: Higher serum ALP level is associated with increased mortality solely in PD patients with RRF
%U https://www.tandfonline.com/doi/full/10.1080/0886022X.2019.1646662