%0 Journal Article
%T On the Aqueous Solution Behavior of C-Substituted 3,1,2-Ruthenadicarbadodecaboranes
%J Inorganics | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/inorganics7070091
%X 3,1,2-Ruthenadicarbadodecaborane complexes bearing the [C 2B 9H 11] 2£¿ (dicarbollide) ligand are robust scaffolds, with exceptional thermal and chemical stability. Our previous work has shown that these complexes possess promising anti-tumor activities in vitro, and tend to form aggregates (or self-assemblies) in aqueous solutions. Here, we report on the synthesis and characterization of four ruthenium(II) complexes of the type [3-( ¦Ç 6-arene)-1,2-R 2-3,1,2-RuC 2B 9H 9], bearing either non-polar (R = Me ( 2¨C 4)) or polar (R = CO 2Me ( 7)) substituents at the cluster carbon atoms. The behavior in aqueous solution of complexes 2, 7 and the parent unsubstituted [3-( ¦Ç 6- p-cymene)-3,1,2-RuC 2B 9H 11] ( 8) was investigated via UV-Vis spectroscopy, mass spectrometry and nanoparticle tracking analysis (NTA). All complexes showed spontaneous formation of self-assemblies (10 8¨C10 9 particles mL £¿1), at low micromolar concentration, with high polydispersity. For perspective applications in medicine, there is thus a strong need for further characterization of the spontaneous self-assembly behavior in aqueous solutions for the class of neutral metallacarboranes, with the ultimate scope of finding the optimal conditions for exploiting this self-assembling behavior for improved biological performance. View Full-Tex
%U https://www.mdpi.com/2304-6740/7/7/91