%0 Journal Article
%T Electronic Effects of the Substituents on Relaxometric and CEST Behaviour of Ln(III)-DOTA-Tetraanilides
%J Inorganics | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/inorganics7040043
%X Three different 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetamide (DOTAM) derivatives bearing as amide N-substituents phenyl, p-methoxyphenyl and p-ethylbenzoate groups were synthesized and the 1H and 17O NMR relaxometric behaviour of the Gd(III)-chelates and chemical exchange saturation transfer (CEST) effect of the Eu(III) complexes were evaluated. The electronic properties of the substituents were shown to strongly influence the coordinated water exchange rate ( k ex), resulting in five times faster k ex for the electron donating phenylmethoxy group compared to the electron withdrawing ethylbenzoate group. View Full-Tex
%U https://www.mdpi.com/2304-6740/7/4/43