%0 Journal Article
%T Antihyperuricemia, Antioxidant, and Antibacterial Activities of Tridax procumbens L.
%J Foods | An Open Access Journal from MDPI
%D 2019
%R https://doi.org/10.3390/foods8010021
%X Tridax procumbens L. is a medicinal plant and used as a drink to treat bronchial catarrh, diarrhea, dysentery and liver diseases. In this study, we evaluated the potential use of T. procumbens to treat hyperuricemia, oxidative stress, and bacterial infection. Ethyl acetate extract of this plant was separated to different fractions by column chromatography (CC) using chloroform and methanol as eluents and subjected to xanthine oxidase (XO) inhibitory, antioxidant, and antibacterial assays. The results showed that the F 45每47 fraction exhibited the strongest XO inhibitory activity (IC 50 = 133.17 米g/mL), while the F 48每50 fraction possessed maximum antioxidant activity assessed by DPPH (2,2-diphenyl-2-picrylhydrazyl) and ABTS (2,2＊-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) assays (IC 50 = 0.51 and 1.04 mg/mL, respectively). In addition, the F 4每5 fraction presented the most effective inhibition on the growth of Escherichia coli, Staphylococcus aureus, Bacillus subtilis, and Proteus mirabilis. Gas chromatography-mass spectrophotometry (GS-MS) and liquid chromatography-electrospray ionization-mass spectrophotometry (LC-ESI-MS) results revealed that fatty acids, glycerides, and flavonoids were the major compounds of the F 45每47 fraction. Glycerides, triose sugar alcohols, and fatty acids were dominant compounds of the F 48每50 fraction, while sterols were principal components of the F 4每5 fraction. This study indicated that T. procumbens had potent inhibitory effects on XO inhibitory, antioxidant, and antibacterial activities. These biological activities may be attributed to the presence of fatty acids, flavonoids, and sterols in this plant. It is suggested that T. procumbens can be utilized as a healthy source to develop beverages and foods to treat antihyperuricemia, oxidative stress, and bacterial infection. View Full-Tex
%U https://www.mdpi.com/2304-8158/8/1/21